Publications
Common light chain chickens produce human antibodies of high affinity and broad epitope coverage for...
January 25, 2021
Bispecific antibodies are an important and growing segment in antibody therapeutics, particularly in the immuno-oncology space. Manufacturing of a bispecific antibody with…
Presentations
xPloration®: High Throughput B Cell Profiling for Antibody Discovery from OmniAb Immune Repertoires
April 5, 2020
The success of a therapeutic antibody is directly related to its biological activity, which is a function of the epitope to which it binds on the target, its specificity, its affinity, and its sequence…
Publications
Comparisons of the antibody repertoires of a humanized rodent and humans by high throughput sequencing
January 24, 2020
The humanization of animal model immune systems by genetic engineering has shown great promise for antibody discovery, tolerance studies and for the evaluation of vaccines…
Publications
Expression of human lambda expands the repertoire of OmniChickens
January 23, 2020
Most of the approved monoclonal antibodies used in the clinic were initially discovered in mice. However, many targets of therapeutic interest are highly conserved…
Presentations
OmniTaur™: Ultralong CDR3 cow antibodies for challenging targets
January 1, 2020
Bovine antibodies are unusual in having exceptionally long heavy chain CDR3 regions, with an average length of 25 amino acids, and an ‘ultralong’ subset that can reach >70 amino acids in length…
Presentations
Benchmarking discovery-stage antibodies from OmniChicken (against clinical-stage antibodies from other sources)
December 10, 2019
Presentation by Bill Harriman and Shelley Izquierdo
Presentations
OmniFlic and OmniClic: Transgenic Rat and Chicken Platforms for Human Bispecific Antibody Discovery
September 17, 2019
Presentation by Christel Iffland and Kathryn Ching
Presentations
OmniChicken and OmniClic: Engineering antibody diversity in vivo through transgene design
September 16, 2019
Presentation by Kathryn Ching
Publications
Complementary epitopes and favorable developability of monoclonal anti-LAMP1 antibodies generated using two transgenic animal platforms
July 16, 2019
Monoclonal antibodies (mAbs) for therapeutic applications should be as similar to native human antibodies as possible to minimize their immunogenicity in patients…
Publications
Discovery of high affinity, pan-allelic, and pan- mammalian reactive antibodies against the myeloid checkpoint receptor...
June 27, 2019
Targeting the CD47-signal-regulatory protein α (SIRPα) pathway represents a novel therapeutic approach to enhance anti-cancer immunity by promoting both innate and…
Publications
Production of Transgenic Chickens Using Cultured Primordial Germ Cells and Gonocytes.
January 10, 2019
The unique characteristics of the avian embryo, with its large opaque yolk, have necessitated the development of different approaches to transgenesis from…