Common light chain chickens produce human antibodies of high affinity and broad epitope coverage for...

January 25, 2021

Bispecific antibodies are an important and growing segment in antibody therapeutics, particularly in the immuno-oncology space. Manufacturing of a bispecific antibody with…


xPloration®: High Throughput B Cell Profiling for Antibody Discovery from OmniAb Immune Repertoires

April 5, 2020

The success of a therapeutic antibody is directly related to its biological activity, which is a function of the epitope to which it binds on the target, its specificity, its affinity, and its sequence…


Comparisons of the antibody repertoires of a humanized rodent and humans by high throughput sequencing

January 24, 2020

The humanization of animal model immune systems by genetic engineering has shown great promise for antibody discovery, tolerance studies and for the evaluation of vaccines…


Expression of human lambda expands the repertoire of OmniChickens

January 23, 2020

Most of the approved monoclonal antibodies used in the clinic were initially discovered in mice. However, many targets of therapeutic interest are highly conserved…


OmniTaur™: Ultralong CDR3 cow antibodies for challenging targets

January 1, 2020

Bovine antibodies are unusual in having exceptionally long heavy chain CDR3 regions, with an average length of 25 amino acids, and an ‘ultralong’ subset that can reach >70 amino acids in length…


Ab Initio Antigen Technology

December 9, 2019

Presentation by John S. Burg


OmniFlic and OmniClic: Transgenic Rat and Chicken Platforms for Human Bispecific Antibody Discovery

September 17, 2019

Presentation by Christel Iffland and Kathryn Ching


Complementary epitopes and favorable developability of monoclonal anti-LAMP1 antibodies generated using two transgenic animal platforms

July 16, 2019

Monoclonal antibodies (mAbs) for therapeutic applications should be as similar to native human antibodies as possible to minimize their immunogenicity in patients…


Discovery of high affinity, pan-allelic, and pan- mammalian reactive antibodies against the myeloid checkpoint receptor...

June 27, 2019

Targeting the CD47-signal-regulatory protein α (SIRPα) pathway represents a novel therapeutic approach to enhance anti-cancer immunity by promoting both innate and…


Production of Transgenic Chickens Using Cultured Primordial Germ Cells and Gonocytes.

January 10, 2019

The unique characteristics of the avian embryo, with its large opaque yolk, have necessitated the development of different approaches to transgenesis from…

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