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OmniAb
  • Technology
    • Overview
    • Antigen Design
    • Antibody Generation
      • OmniRat
      • OmniMouse
      • OmniChicken
      • OmniTaur
      • Bispecific Platforms
    • Screening
      • GEM
      • xPloration
    • Discovery
    • Antibody Optimization
  • Why OmniAb
  • Partnerships
  • About
    • Overview
    • Team
    • Publications & Presentations
    • News & Press Releases
    • Careers
  • Contact

OmniMouse®: A transgenic mouse for human antibody discovery

  • Antibody Generation
  • OmniRat
  • OmniMouse
  • OmniChicken
  • OmniTaur
  • Bispecific Platforms

OmniMouse delivers fully human antibodies using standard mouse-based protocols

OmniMouse expands the sequence diversity of the rat platforms (OmniRat® and OmniFlic®), offering easy conversion from wild type mice using the same protocols. Designed with the same transgenes as OmniRat, OmniMouse was launched in 2014.

It produces a diverse repertoire of antibodies with human idiotypes and provides a complementary murine system for additional sequence diversity. OmniMouse is bred on a mixed genetic background to increase the sequence diversity.

Three lines are available that express different choices of light chain isotypes: kappa, lambda, or kappa and lambda, to provide further diversity. This platform can be easily adapted to internal processes using standard protocols.

Scientific Publications

Human Antibody Production in Transgenic Animals

Nucleic acid delivery of immune-focused SARS-CoV-2 nanoparticles drive rapid and potent immunogenicity capable of single-dose protection

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