OmnidAb™: Heavy Chain-Only Transgenic Chicken
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Optimized human VH domain powered by affinity maturation in a chicken host
Single-domain antibodies are small, stable, modular, and manufacturable, making them ideal for various therapeutic applications. OmnidAb is an in vivo chicken host platform for single-domain antibody discovery, based upon an optimized human VH domain that affinity matures to provide a functionally diverse immune repertoire unavailable with mammalian host systems.
![](https://www.omniab.com/wp-content/uploads/2023/11/OmnidAb-Cover-Art-JPG-min.jpg)
Chicken Platforms: Powered by Evolution
Immunization in a chicken host has distinct advantages over rodent models. Their evolutionary distance from humans means a more robust immune response against antigens that are usually weakly immunogenic, unique epitope recognition, and higher antibody titers.
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About OmnidAb
OmnidAb is the first and only transgenic chicken host that can generate humanized single-domain antibodies, enabling greater immune recognition of highly-conserved antigens and the discovery of more diverse antibody repertoires. These can serve in a variety of applications, including as building blocks for bi- or multi-specific therapeutics.
OmnidAb features:
- Heavy chain-only VH transgene contains human VH3-23 with 10 stabilizing mutations in the framework, with no non-canonical cysteines or post-translational modification liabilities.
- Produces high-affinity, antigen-specific, single-domain antibodies with good developability metrics and high expression levels in mammalian cells.
- Generates robust B-cell development and antibody titers following immunization.
- More diverse repertoires against distinct epitopes, compared to other animal hosts.