The Antigen Design
Platform
Proven success with high-value and difficult targets
OmniAb offers computationally powered antigen design for production of challenging therapeutic targets. The antigen platform produces full-length membrane proteins, including multi-Tm proteins such as ion channels and G protein-coupled receptors (GPCRs), the largest class of therapeutic drug targets.
Antigen production works in tandem with our therapeutic antibody discovery platform, providing access to high-quality, functionally validated membrane protein antigens for immunization campaigns.
Multi-faceted antigen design leverages years of experience and a range of technologies
Guided by molecular modeling and protein design capabilities, our team manages the cloning, expression, purification, reconstitution, and quality control of purified native-conformation membrane proteins for immunization and screening purposes.
Designer antigens to stimulate the right immune response
Antigens can be prepared in particular conformations with protein or small molecule conformational chaperones. The range of accessible antigen formats maximizes the chance of success in generating robust immune responses with desired specificities from any of the OmniAb antibody platforms.
Multi-faceted antigen design leverages years of experience and a range of technologies
Use modeling and design, cloning, expression, purification, reconstitution, quality control of highly purified native membrane proteins and immunizations, and other antigen production methods.
Designer Antigens to Stimulate the Right Immune Response
Display antigen in particular conformations with protein or small molecule conformational chaperones. The high quality, stability, and variety of available formats maximize the chance of success in generating robust immune response with any of the OmniAb antibody platforms.