OmniRat® & OmniFlic®: Transgenic rodents for human antibody discovery
The only human Ig-transgenic rats for the discovery of therapeutic antibodies
If you’re looking for transgenic rat antibodies, you’ve come to the right place. OmniRat and OmniFlic are the only rats made with transgenic technology available for the generation of monospecific and bispecific human antibodies. These animal platforms have been extensively validated and boast a strong record of clinical development success. You can depend on our transgenic rat model for your upcoming experiments.
OmniAb supports humanized rat antibody research because of the key role that rats play in numerous experimental studies.
About OmniRat
Launched in 2012, OmniRat was the first example of a successful knock-out of the endogenous rat immunoglobulin genes coupled with transgenesis of the human counterparts. They fill a profound need for genetically modified rats with consistent characteristics.
OmniRat produces a diverse repertoire of antibodies with human idiotypes and similar immunological characteristics as rat antibodies from wildtype animals. When cross-reactivity against mouse is required, OmniRat is the first choice as a rodent platform.
Rat antibodies compared to mouse antibodies
If you’re still gathering data on which species to work with in your lab, consider the following differences between rat and mouse antibodies for research. You’ll find significant advantages when you employ rat monoclonal antibodies in your work:
* Rat monoclonal antibodies have lower antigen requirements.
* Researchers can obtain higher lymphocyte yields with rats.
* In sandwich assays, rat antibodies are more efficient in pairing than mouse antibodies.
OmniRat features:
- Contains functional recombinant immunoglobulin loci
- Rearranges functional human Ig genes
- Uses genes with similar frequency as humans
- Shows normal human CDR3 length distribution
- Demonstrates normal B cell development
- Shows high expression of immunoglobulins
- Displays normal hypermutation and affinity maturation
OmniFlic: a fixed light-chain variation of OmniRat
The OmniFlic transgenic rat expresses a fixed VK3-15 light chain so different antibodies generated using this platform can be easily combined to form a bispecific human antibody.
Contact OmniAb today to learn more about OmniRat
The advantages of working with OmniAb are clear. We’re known for being an industry leader in developing transgenic animals for industry partners in the United States and around the globe. Our transgenic rat antibody research team is dedicated to developing technologies that facilitate the discovery of therapeutic antibodies.
To find out more about how OmniRat can help your organization in crucial drug discovery research, contact us today.