The only human Ig-transgenic chicken for the discovery of therapeutic antibodies
More than 300 million years of evolutionary distance drives divergence between mammalian and avian orthologs. Our genetically modified chicken, the OmniChicken and OmniClic, offer affinity matured antibodies in an evolutionarily distant chicken host environment, which can deliver a diverse repertoire of antibody panels to highly conserved therapeutic targets. When it comes to transgenic chicken production, OmniAb’s chicken antibody research supports work being done in laboratories across the United States.
Leverage the advantage of using distinct transgenic animals
Due to the large evolutionary distance between birds and mammals, many target antigens that are not immunogenic in rats or mice induce a strong antibody response in chickens. Indeed, scientists consider chickens to be an ideal host for generating antibodies against mammalian or human protein antigens. This insight has led to OmniAb’s ongoing work in transgenic chicken antibody research.
Chief advantages of using transgenic chicken antibodies include:
* Chickens react to mammalian genes as foreign, prompting a strong immune response desired by scientific researchers. This has resulted in increased demand in the lab for a validated genetically engineered chicken.
* Chicken antibodies are more stable than mammalian antibodies, with a longer shelf life when properly stored under climate control.
* You can produce higher signals during tests due to the bigger glycosylation index, enabling more HRP labeling.
Launched in 2016, OmniChicken is the first successfully genetically altered chicken with an immune system that can efficiently generate human sequence antibody repertoires.
About OmniClic: A transgenic chicken that generates bispecific antibodies
OmniClic transgenic chickens express a fixed VK3-15 light chain so different antibodies generated using this platform can be easily combined to form a bispecific human antibody.
Questions about OmniChicken? Connect with OmniAb today
At OmniAb, we’re proud of our reputation in the transgenic research animals industry. We are the only company offering chickens made with transgenic technology, and we welcome any questions you might have. To discover how our OmniChicken can fit into your laboratory’s workflow, get in touch with us today.