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OmniAb
  • Technology
    • Overview
    • Antigen Design
    • Antibody Generation
      • OmniRat
      • OmniMouse
      • OmniChicken
      • OmniTaur
      • Bispecific Platforms
    • Screening
      • GEM
      • xPloration
    • Discovery
    • Antibody Optimization
  • Why OmniAb
  • Partnerships
  • About
    • Overview
    • Team
    • Publications & Presentations
    • News & Press Releases
    • Careers
  • Contact

OmniTaur™: Cow-inspired antibodies

  • Antibody Generation
  • OmniRat
  • OmniMouse
  • OmniChicken
  • OmniTaur
  • Bispecific Platforms

Cow-inspired ultralong H3 antibodies with a humanized framework

Launched in 2020, OmniTaur provides cow-inspired ultralong H3 antibodies with a humanized framework. These unique antibodies have been shown to bind to targets that may be difficult to reach with conventional antibodies, making them ideal for the study of antivirals and channel blockers, among other therapies.

Fully humanized cow scaffold:

  • Enables therapeutic use
  • Human IgG constant region
  • CDRH3 'knob' has potential to be expressed independently as a 'picobody'
  • Enables targeting of ion channels, transporters, viral proteins, and other challenging targets with deep pockets or cryptic epitopes

Scientific Publications

Conservation and diversity in the ultralong third heavy-chain complementarity-determining region of bovine antibodies

Rapid elicitation of broadly neutralizing antibodies to HIV by immunization in cows

Structural basis of broad HIV neutralization by a vaccine-induced cow antibody

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