Scientific Publications
Publications
Antigen-specific single B cell sorting and expression-cloning from immunoglobulin humanized rats: a rapid and versatile...
Publications
BMC Biotechnology, 2017
There is an ever-increasing need of monoclonal antibodies (mAbs) for biomedical applications and fully human binders are particularly desirable due ...
Publications
High-efficiency antibody discovery achieved with multiplexed microscopy.
Publications
Microscopy (Oxf), 2016
The analysis of secreted antibody from large and diverse populations of B cells in parallel at the clonal level can ...
Publications
Assessing kinetic and epitopic diversity across orthogonal monoclonal antibody generation platforms.
Publications
MAbs, 2016
The ability of monoclonal antibodies (mAbs) to target specific antigens with high precision has led to an increasing demand to ...
Publications
Expression of heavy chain-only antibodies can support B-cell development in light chain knockout chickens.
Publications
Eur. J. Immunol., 2016
Since the discovery of antibody-producing B cells in chickens six decades ago, chickens have been a model for B-cell development ...
Publications
Germline Gene Editing in Chickens by Efficient CRISPR-Mediated Homologous Recombination in Primordial Germ cells.
Publications
PLOS ONE, 2016
The CRISPR/Cas9 system has been applied in a large number of animal and plant species for genome editing. In chickens, ...
Publications
Generation of chickens expressing Cre recombinase.
Publications
Transgenic Research, 2016
Cre recombinase has been extensively used for genome engineering in transgenic mice yet its use in other species has been ...
Publications
Inserting random and site-specific changes into the genome of chickens.
Publications
Poult Sci., 2015
During the past decade, modifications to the chicken genome have evolved from random insertions of small transgenes using viral vectors ...
Publications
A Diverse Repertoire of Human Immunoglobulin Variable Genes in a Chicken B Cell Line is...
Publications
Front Immunol, 2015
Chicken immune responses to human proteins are often more robust than rodent responses because of the phylogenetic relationship between the ...
Publications
Human Antibody Production in Transgenic Animals
Publications
Arch. Immunol. Ther. Exp., 2015
Fully human antibodies from transgenic animals account for an increasing number of new therapeutics. After immunization, diverse human monoclonal antibodies ...
Publications
Transgenic Animals Derived by DNA Microinjection.
Publications
Handbook of Therapeutic Antibodies, 2014
Human antibody expression in transgenic rodents has been significantly improved by the integration of large chimeric DNA constructs linking human ...
Publications
Human antibody expression in transgenic rats: Comparison of chimeric IgH loci with human VH, D...
Publications
Journal of Immunological Methods, 2013
Expression of human antibody repertoires in transgenic animals has been accomplished by introducing large human Ig loci into mice and, ...
Publications
Immunoglobulin knockout chickens via efficient homologous recombination in primordial germ cells.
Publications
Proc Natl Acad Sci USA, 2013
Gene targeting by homologous recombination or by sequence-specific nucleases allows the precise modification of genomes and genes to elucidate their ...