Scientific Publications

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Publications (28)

Publications

Antigen-specific single B cell sorting and expression-cloning from immunoglobulin humanized rats: a rapid and versatile...

BMC Biotechnology, 2017

There is an ever-increasing need of monoclonal antibodies (mAbs) for biomedical applications and fully human binders are particularly desirable due ...
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Publications

High-efficiency antibody discovery achieved with multiplexed microscopy.

Microscopy (Oxf), 2016

The analysis of secreted antibody from large and diverse populations of B cells in parallel at the clonal level can ...
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Publications

Assessing kinetic and epitopic diversity across orthogonal monoclonal antibody generation platforms.

MAbs, 2016

The ability of monoclonal antibodies (mAbs) to target specific antigens with high precision has led to an increasing demand to ...
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Publications

Expression of heavy chain-only antibodies can support B-cell development in light chain knockout chickens.

Eur. J. Immunol., 2016

Since the discovery of antibody-producing B cells in chickens six decades ago, chickens have been a model for B-cell development ...
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Publications

Germline Gene Editing in Chickens by Efficient CRISPR-Mediated Homologous Recombination in Primordial Germ cells.

PLOS ONE, 2016

The CRISPR/Cas9 system has been applied in a large number of animal and plant species for genome editing. In chickens, ...
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Publications

Generation of chickens expressing Cre recombinase.

Transgenic Research, 2016

Cre recombinase has been extensively used for genome engineering in transgenic mice yet its use in other species has been ...
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Publications

Inserting random and site-specific changes into the genome of chickens.

Poult Sci., 2015

During the past decade, modifications to the chicken genome have evolved from random insertions of small transgenes using viral vectors ...
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Publications

A Diverse Repertoire of Human Immunoglobulin Variable Genes in a Chicken B Cell Line is...

Front Immunol, 2015

Chicken immune responses to human proteins are often more robust than rodent responses because of the phylogenetic relationship between the ...
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Publications

Human Antibody Production in Transgenic Animals

Arch. Immunol. Ther. Exp., 2015

Fully human antibodies from transgenic animals account for an increasing number of new therapeutics. After immunization, diverse human monoclonal antibodies ...
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Publications

Transgenic Animals Derived by DNA Microinjection.

Handbook of Therapeutic Antibodies, 2014

Human antibody expression in transgenic rodents has been significantly improved by the integration of large chimeric DNA constructs linking human ...
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Publications

Human antibody expression in transgenic rats: Comparison of chimeric IgH loci with human VH, D...

Journal of Immunological Methods, 2013

Expression of human antibody repertoires in transgenic animals has been accomplished by introducing large human Ig loci into mice and, ...
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Publications

Immunoglobulin knockout chickens via efficient homologous recombination in primordial germ cells.

Proc Natl Acad Sci USA, 2013

Gene targeting by homologous recombination or by sequence-specific nucleases allows the precise modification of genomes and genes to elucidate their ...
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