Scientific Publications
Publications
Transgenic Animals Derived by DNA Microinjection.
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Handbook of Therapeutic Antibodies, 2014
Human antibody expression in transgenic rodents has been significantly improved by the integration of large chimeric DNA constructs linking human ...
Publications
Human antibody expression in transgenic rats: Comparison of chimeric IgH loci with human VH, D...
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Journal of Immunological Methods, 2013
Expression of human antibody repertoires in transgenic animals has been accomplished by introducing large human Ig loci into mice and, ...
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Immunoglobulin knockout chickens via efficient homologous recombination in primordial germ cells.
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Proc Natl Acad Sci USA, 2013
Gene targeting by homologous recombination or by sequence-specific nucleases allows the precise modification of genomes and genes to elucidate their ...
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Harnessing gene conversion in chicken B cells to create a human antibody sequence repertoire.
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PLOS ONE, 2013
Transgenic chickens expressing human sequence antibodies would be a powerful tool to access human targets and epitopes that have been ...
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High-Affinity IgG Antibodies Develop Naturally in Ig-Knockout Rats Carrying Germline Human IgH/Igk/Igl Loci...
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J Immunol., 2013
Mice transgenic for human Ig loci are an invaluable resource for the production of human Abs. However, such mice often ...
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Characterization of immunoglobulin heavy chain knockout rats
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Eur. J. Immunol., 2010
The rat is a species frequently used in immunological studies but, until now, there were no models with introduced gene-specific ...
Publications
Knockout Rats via Embryo Microinjection of Zinc-Finger Nucleases
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Science, 2009
The toolbox of rat genetics currently lacks the ability to introduce site-directed, heritable mutations into the genome to create knockout ...