Scientific Publications

The humanization of animal model immune systems by genetic engineering has shown great promise for antibody discovery, tolerance studies and ...

Most of the approved monoclonal antibodies used in the clinic were initially discovered in mice. However, many targets of therapeutic ...

Bovine antibodies are unusual in having exceptionally long heavy chain CDR3 regions, with an average length of 25 amino acids, ...

Presentation by Christel Iffland and Kathryn Ching ...

Monoclonal antibodies (mAbs) for therapeutic applications should be as similar to native human antibodies as possible to minimize their immunogenicity ...

Targeting the CD47-signal-regulatory protein α (SIRPα) pathway represents a novel therapeutic approach to enhance anti-cancer immunity by promoting both innate ...

The unique characteristics of the avian embryo, with its large opaque yolk, have necessitated the development of different approaches to ...

Transgenic animal platforms for the discovery of human monoclonal antibodies have been developed in mice, rats, rabbits and cows. The ...

An important characteristic of chickens is that the antibody repertoire is based on a single framework, with diversity found mainly ...

We created a novel transgenic rat that expresses human antibodies comprising a diverse repertoire of heavy chains with a single ...

Identifying monoclonal antibodies that block human voltage-gated ion channels (VGICs) is a challenging endeavor exacerbated by difficulties in producing recombinant ...

Oligomannose-type glycans are among the major targets on the gp120 component of the HIV envelope protein (Env) for broadly neutralizing ...