Scientific Publications

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Presentations (12)

Publications (28)

Presentations

Antigen Design Technology

2019

Presentation by John S. Burg ...
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Presentations

OmniFlic and OmniClic: Transgenic Rat and Chicken Platforms for Human Bispecific Antibody Discovery

2019

Presentation by Christel Iffland and Kathryn Ching ...
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Presentations

OmniChicken and OmniClic: Engineering antibody diversity in vivo through transgene design

2019

Presentation by Kathryn Ching ...
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Publications

Complementary epitopes and favorable developability of monoclonal anti-LAMP1 antibodies generated using two transgenic animal platforms

2019

Monoclonal antibodies (mAbs) for therapeutic applications should be as similar to native human antibodies as possible to minimize their immunogenicity ...
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Publications

Discovery of high affinity, pan-allelic, and pan- mammalian reactive antibodies against the myeloid checkpoint receptor...

2019

Targeting the CD47-signal-regulatory protein α (SIRPα) pathway represents a novel therapeutic approach to enhance anti-cancer immunity by promoting both innate ...
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Publications

Production of Transgenic Chickens Using Cultured Primordial Germ Cells and Gonocytes.

Methods Mol Biol, 2019

The unique characteristics of the avian embryo, with its large opaque yolk, have necessitated the development of different approaches to ...
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Publications

Chickens with humanized immunoglobulin genes generate antibodies with high affinity and broad epitope coverage to...

MAbs, 2018

Transgenic animal platforms for the discovery of human monoclonal antibodies have been developed in mice, rats, rabbits and cows. The ...
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Publications

V(D)J Rearrangement Is Dispensable for Producing CDR-H3 Sequence Diversity in a Gene Converting...

Front Immunol., 2018

An important characteristic of chickens is that the antibody repertoire is based on a single framework, with diversity found mainly ...
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Publications

Sequence-Based Discovery Demonstrates That Fixed Light Chain Human Transgenic Rats Produce a Diverse Repertoire of...

Front. Immunol., 2018

We created a novel transgenic rat that expresses human antibodies comprising a diverse repertoire of heavy chains with a single ...
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Publications

A multiplatform strategy for the discovery of conventional monoclonal antibodies that inhibit the voltage-gated potassium...

MAbs, 2018

Identifying monoclonal antibodies that block human voltage-gated ion channels (VGICs) is a challenging endeavor exacerbated by difficulties in producing recombinant ...
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Publications

Bacterially derived synthetic mimetics of mammalian oligomannose prime antibody responses that neutralize HIV infectivity

Nature Communications, 2017

Oligomannose-type glycans are among the major targets on the gp120 component of the HIV envelope protein (Env) for broadly neutralizing ...
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Publications

Generation of a highly diverse panel of antagonistic chicken monoclonal antibodies against the GIP receptor.

MAbs, 2017

Raising functional antibodies against G protein-coupled receptors (GPCRs) is challenging due to their low density expression, instability in the absence ...
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