Scientific Publications
Presentations
Opening the Barn Door to Antibody Discovery
Presentations
Antibody Engineering & Therapeutics Conference, 2022
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Presentations
Discovery, Expression, and Characterization of Neutralizing Picobodies against SARS-CoV2
Presentations
Antibody Engineering and Therapeutics, 2021
At 4-6 KD, “picobodies” represent the smallest known Ig-derived binding moiety capable of high affinity interactions with target proteins ...
Publications
Common light chain chickens produce human antibodies of high affinity and broad epitope coverage for...
Publications
MAbs, 2021
Bispecific antibodies are an important and growing segment in antibody therapeutics, particularly in the immuno-oncology space. Manufacturing of a bispecific ...
Publications
Comparisons of the antibody repertoires of a humanized rodent and humans by high throughput sequencing
Publications
2020
The humanization of animal model immune systems by genetic engineering has shown great promise for antibody discovery, tolerance studies and ...
Publications
Expression of human lambda expands the repertoire of OmniChickens
Publications
PLOS ONE, 2020
Most of the approved monoclonal antibodies used in the clinic were initially discovered in mice. However, many targets of therapeutic ...
Presentations
OmniTaur™: Ultralong CDR3 cow antibodies for challenging targets
Presentations
2020
Bovine antibodies are unusual in having exceptionally long heavy chain CDR3 regions, with an average length of 25 amino acids, ...
Presentations
OmniFlic and OmniClic: Transgenic Rat and Chicken Platforms for Human Bispecific Antibody Discovery
Presentations
2019
Presentation by Christel Iffland and Kathryn Ching ...
Publications
Complementary epitopes and favorable developability of monoclonal anti-LAMP1 antibodies generated using two transgenic animal platforms
Publications
2019
Monoclonal antibodies (mAbs) for therapeutic applications should be as similar to native human antibodies as possible to minimize their immunogenicity ...
Publications
Discovery of high affinity, pan-allelic, and pan- mammalian reactive antibodies against the myeloid checkpoint receptor...
Publications
2019
Targeting the CD47-signal-regulatory protein α (SIRPα) pathway represents a novel therapeutic approach to enhance anti-cancer immunity by promoting both innate ...
Publications
Production of Transgenic Chickens Using Cultured Primordial Germ Cells and Gonocytes.
Publications
Methods Mol Biol, 2019
The unique characteristics of the avian embryo, with its large opaque yolk, have necessitated the development of different approaches to ...
