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OmniAb
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      • OmniRat
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    • Screening
      • GEM
      • xPloration
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OmniAb
  • About
    • Overview
    • Team
    • Board of Directors
    • Careers
  • Technology
    • Overview
    • Antigen Design
    • Antibody Generation
      • OmniRat
      • OmniMouse
      • OmniChicken
      • OmniTaur
      • Bispecific Platforms
    • Screening
      • GEM
      • xPloration
    • Antibody Optimization
    • Ion Channel and Transporter Technology
    • Scientific Publications
  • Partnerships
    • Overview
    • Why Partner with OmniAb?
    • Partner Pipeline
    • Contact Business Development
  • Investors
    • Overview
    • News
    • Events & Presentations
    • Stock Info
    • SEC Filings
    • Governance
      • Governance Documents
      • Executive Officers
      • Board of Directors
      • Board Committees
    • Resources
      • Investor FAQs
      • Information Request Form
      • Investor Email Alerts
      • Investor Contacts
  • Contact

Screening for monoclonal antibodies with GEM

  • Screening
  • GEM
  • xPloration

A robust and versatile B-cell discovery workflow that maximizes screening options

Gel Encapsulated Microenvironment (GEM) technology involves isolating single B-cells from an immunized animal into small droplets containing Reporters that present the target antigen on the surface of a bead or cell.

Secreted antibodies diffuse locally and have the opportunity to bind to Reporters, which in turn can be detected through a fluorescent probe. Antigen specificity is determined by colocalization of signal with alternative bead and/or cell types.

Including different types of Reporters in a single experiment can generate a multi-parameter binding profile of each antibody. Millions of GEMs can be queried in parallel in a fluorescence microscopy environment.

GEMs containing B-cells and antibodies of interest can be harvested, cloned, and expressed as recombinant antibodies for further characterization studies.

About

  • Overview
  • Team
  • Board of Directors
  • Careers

Partnerships

  • Overview
  • Why Partner with OmniAb?
  • Partner Pipeline
  • Contact Business Development

Technology

  • Overview
  • Antigen Design
  • Antibody Generation
  • Screening
  • Antibody Optimization
  • Ion Channel and Transporter Technology
  • Scientific Publications

OmniAb, Inc.
5980 Horton Street
Suite 600
Emeryville, CA 94608

[email protected]
[email protected]

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