xPloration^® AI-powered B-cell screening for antibody discovery

OmniAb’s AI-powered xPloration screening incorporates principles of the GEM assay in a high throughput, automated modality. Its through-hole format enables the examination of millions of antibody secreting cells and the proprietary laser recovery method recovers thousands of sequences in minutes.

xPloration uses chips with ~1.5M capillaries to separate individual secreting B-cells in the presence of Reporters. Chips are processed through automated imaging, then analyzed through AI-powered algorithms to identify B-cells that express antibodies with the desired binding profiles. Rapidly recover individual B-cells from selected capillaries by laser injection for processing of B-cell nucleic acids for sequencing and expression cloning.

xPloration enables:

• Bolstered antibody discovery output for partner campaigns using OmniChicken^® and OmniClic^®.
• Optimized antibody discovery efficiency through new types of functional screening assays
• Anticipated support for the entire suite of OmniAb animals