Scientific Publications
Publications
A multiplatform strategy for the discovery of conventional monoclonal antibodies that inhibit the voltage-gated potassium...
Publications
MAbs, 2018
Identifying monoclonal antibodies that block human voltage-gated ion channels (VGICs) is a challenging endeavor exacerbated by difficulties in producing recombinant ...
Publications
Bacterially derived synthetic mimetics of mammalian oligomannose prime antibody responses that neutralize HIV infectivity
Publications
Nature Communications, 2017
Oligomannose-type glycans are among the major targets on the gp120 component of the HIV envelope protein (Env) for broadly neutralizing ...
Publications
Generation of a highly diverse panel of antagonistic chicken monoclonal antibodies against the GIP receptor.
Publications
MAbs, 2017
Raising functional antibodies against G protein-coupled receptors (GPCRs) is challenging due to their low density expression, instability in the absence ...
Publications
Antigen-specific single B cell sorting and expression-cloning from immunoglobulin humanized rats: a rapid and versatile...
Publications
BMC Biotechnology, 2017
There is an ever-increasing need of monoclonal antibodies (mAbs) for biomedical applications and fully human binders are particularly desirable due ...
Publications
High-efficiency antibody discovery achieved with multiplexed microscopy.
Publications
Microscopy (Oxf), 2016
The analysis of secreted antibody from large and diverse populations of B cells in parallel at the clonal level can ...
Publications
Assessing kinetic and epitopic diversity across orthogonal monoclonal antibody generation platforms.
Publications
MAbs, 2016
The ability of monoclonal antibodies (mAbs) to target specific antigens with high precision has led to an increasing demand to ...
Publications
Expression of heavy chain-only antibodies can support B-cell development in light chain knockout chickens.
Publications
Eur. J. Immunol., 2016
Since the discovery of antibody-producing B cells in chickens six decades ago, chickens have been a model for B-cell development ...
Publications
Germline Gene Editing in Chickens by Efficient CRISPR-Mediated Homologous Recombination in Primordial Germ cells.
Publications
PLOS ONE, 2016
The CRISPR/Cas9 system has been applied in a large number of animal and plant species for genome editing. In chickens, ...
Publications
Generation of chickens expressing Cre recombinase.
Publications
Transgenic Research, 2016
Cre recombinase has been extensively used for genome engineering in transgenic mice yet its use in other species has been ...
Publications
Inserting random and site-specific changes into the genome of chickens.
Publications
Poult Sci., 2015
During the past decade, modifications to the chicken genome have evolved from random insertions of small transgenes using viral vectors ...
Publications
A Diverse Repertoire of Human Immunoglobulin Variable Genes in a Chicken B Cell Line is...
Publications
Front Immunol, 2015
Chicken immune responses to human proteins are often more robust than rodent responses because of the phylogenetic relationship between the ...
Publications
Human Antibody Production in Transgenic Animals
Publications
Arch. Immunol. Ther. Exp., 2015
Fully human antibodies from transgenic animals account for an increasing number of new therapeutics. After immunization, diverse human monoclonal antibodies ...