OmniChicken® & OmniClic®: Transgenic chickens for human antibody discovery
The only human Ig-transgenic chicken for the discovery of therapeutic antibodies
Leverage the advantage of using distinct transgenic animals
Due to the large evolutionary distance between birds and mammals, many target antigens that are not immunogenic in rats or mice induce a strong antibody response in chickens. Indeed, scientists consider chickens to be an ideal host for generating antibodies against mammalian or human protein antigens. This insight has led to OmniAb’s ongoing work in transgenic chicken antibody research.
Chief advantages of using transgenic chicken antibodies include:
* Chickens react to mammalian genes as foreign, prompting a strong immune response desired by scientific researchers. This has resulted in increased demand in the lab for a validated genetically engineered chicken.
* Chicken antibodies are more stable than mammalian antibodies, with a longer shelf life when properly stored under climate control.
* You can produce higher signals during tests due to the bigger glycosylation index, enabling more HRP labeling.
About OmniChicken
Launched in 2016, OmniChicken is the first successfully genetically altered chicken with an immune system that can efficiently generate human sequence antibody repertoires.
OmniChicken features:
- A high level of functional antibody diversity is achieved through the powerful in vivo diversification process of gene conversion.
- Patented genetic design focuses diversity in the CDR regions while maintaining conserved and highly developable framework regions based on human VH3-23 and VK3-15 or VL1-44
- OmniChicken antibodies bind to diverse epitopes on human targets with high affinity, and typically feature excellent developability profiles
About OmniClic: A transgenic chicken that generates bispecific antibodies
OmniClic transgenic chickens express a fixed VK3-15 light chain so different antibodies generated using this platform can be easily combined to form a bispecific human antibody.
Questions about OmniChicken? Connect with OmniAb today
At OmniAb, we’re proud of our reputation in the transgenic research animals industry. We are the only company offering chickens made with transgenic technology, and we welcome any questions you might have. To discover how our OmniChicken can fit into your laboratory’s workflow, get in touch with us today.