xPloration® AI-powered B-cell screening for antibody discovery
Screen millions of single B cells and recover thousands of unique antibody variants within hours
xPloration represents a significant advancement in single B-cell screening and antibody discovery. OmniAb’s AI-powered xPloration utilizes a through-hole format that enables the examination of millions of antibody secreting cells and a proprietary laser recovery method support the quick recovery of thousands of sequences.
xPloration uses chips with ~1.5M capillaries to separate individual secreting B-cells in the presence of reporter cells or beads. Chips are processed through automated imaging, then analyzed using computer vision models to identify B-cells that express antibodies with the desired binding profiles. These positive hits are rapidly recovered by laser extraction, after which their antibody sequences are determined.
xPloration is designed to:
- Bolstered antibody discovery output for partner campaigns using the entire suite of OmniAb transgenic animals
- Optimized antibody discovery efficiency through new types of functional screening assays and large-scale mining of repertoires
OmniAb recently introduced the xPloration Partner Access Program
The partner access program allows partners to purchase the instrument for use in their own laboratories. With a robust, user-friendly design and rapid instrument run times of approximately 1.5 hours, xPloration meets the evolving discovery needs of the biopharmaceutical industry. It excels in screening and cell recovery, outperforming other spatial separation techniques, and enables the discovery of rare cells that may be missed by competing systems. The instrument’s laser-based recovery process enhances discovery efficiency. Additionally, its fluidics-free system and simple guided interface facilitates setup with minimal calibrations while boosting ease of use and reliability.
Our partners can now experience the advantages of xPloration’s fast processing speed, exceptional hit recovery, unparalleled ease-of-use and reliability in their own laboratories.