Broadcasts
Publications and Presentations
Discovery, Expression, and Characterization of Neutralizing Picobodies against SARS-CoV2
At 4-6 KD, “picobodies” represent the smallest known Ig-derived binding moiety capable of high affinity interactions with target proteins.
Discovery, Expression, and Characterization of Neutralizing Picobodies against SARS-CoV2 Read More »
Common light chain chickens produce human antibodies of high affinity and broad epitope coverage for the engineering of bispecifics
Bispecific antibodies are an important and growing segment in antibody therapeutics, particularly in the immuno-oncology space. Manufacturing of a bispecific antibody with…
Comparisons of the antibody repertoires of a humanized rodent and humans by high throughput sequencing
The humanization of animal model immune systems by genetic engineering has shown great promise for antibody discovery, tolerance studies and for the evaluation of vaccines…
Expression of human lambda expands the repertoire of OmniChickens
Most of the approved monoclonal antibodies used in the clinic were initially discovered in mice. However, many targets of therapeutic interest are highly conserved…
Expression of human lambda expands the repertoire of OmniChickens Read More »
OmniTaur™: Ultralong CDR3 cow antibodies for challenging targets
Bovine antibodies are unusual in having exceptionally long heavy chain CDR3 regions, with an average length of 25 amino acids, and an ‘ultralong’ subset that can reach >70 amino acids in length…
OmniTaur™: Ultralong CDR3 cow antibodies for challenging targets Read More »
Complementary epitopes and favorable developability of monoclonal anti-LAMP1 antibodies generated using two transgenic animal platforms
Monoclonal antibodies (mAbs) for therapeutic applications should be as similar to native human antibodies as possible to minimize their immunogenicity in patients…
Discovery of high affinity, pan-allelic, and pan- mammalian reactive antibodies against the myeloid checkpoint receptor SIRPα
Targeting the CD47-signal-regulatory protein α (SIRPα) pathway represents a novel therapeutic approach to enhance anti-cancer immunity by promoting both innate and…
Production of Transgenic Chickens Using Cultured Primordial Germ Cells and Gonocytes.
The unique characteristics of the avian embryo, with its large opaque yolk, have necessitated the development of different approaches to transgenesis from…
Production of Transgenic Chickens Using Cultured Primordial Germ Cells and Gonocytes. Read More »