OmniTides™: Naturally Optimized In Vivo Peptide Discovery

OmniTides is a versatile in vivo peptide discovery platform, enabling the discovery of tailored, naturally optimized peptides for multiple therapeutic applications. The OmniTides platform delivers peptides pre-optimized for specificity, affinity, and structural stability, streamlining hit-to-lead identification.

One discovery platform for advanced peptide discovery.

The OmniTides platform redefines peptide discovery, and is ideal for applications such as multispecifics, targeted payload delivery (radioligands, drug conjugates, oligos), CAR-T and stand-alone peptide therapeutics.

Flexibility for structured peptides and custom conjugates

Use the peptides alone or tethered to other scaffolds to develop targeted conjugates and multispecifics, leveraging small size and autonomous binding capability for optimal building blocks in format-agnostic therapeutic intervention.

In vivo optimized

Generate diverse, target-specific repertoires of peptides, powered by natural immune systems and optimized for therapeutic target engagement.

OmniTide™ libraries are enriched for pre-optimized sequences

Generate unique peptides with built-in specificity, affinity, and stability, accelerating hit-to-lead identification.

Uniquely access an array of difficult targets

OmniTides benefits from the evolutionary advantage of a chicken host for expanded epitope coverage of human targets including those considered otherwise undruggable.

The OmniTides platform enables multiple therapeutic applications:

  • Standalone peptide therapeutics: In vivo generation of functional structured peptides offers a unique and versatile approach to identify novel therapeutic peptides, expanding beyond traditional peptide discovery techniques. 
  • Peptide conjugate therapeutics: With their small size and rapid clearance, OmniTides-derived peptides are ideally suited for tissue-specific delivery of a range of important therapeutic payloads including theranostic radioligands small molecule toxins and oligonucleotides. 
  • Multispecific therapeutics: With a diverse array of conjugation possibilities, OmniTides-derived peptides enable the versatile construction of a range of multispecific modalities for enhanced therapeutic impact.
  • CAR-T therapy: OmniTides peptides provide flexible binding units for CAR-T constructs or targeted delivery molecules, enabling precise recognition and destruction of cancer cells.