Scientist Antibody Engineering & Protein Sciences

The Scientist position will report to the leader of the Protein Chemistry group and will support therapeutic antibody discovery campaigns.  This position will focus on antibody characterization and optimization. A successful candidate will have strong technical skills and hands-on experience in biochemistry, molecular biology, structural biology or a related field. Must be able to independently design and execute experiments. Must have a good theoretical understanding of protein chemistry. Strong communication and collaboration skills are required. 

The OmniAb group at Ligand consists of dynamic and innovative scientists that employ a variety of novel platforms to support our partners in discovering the best antibodies possible for their therapeutic applications.  At the core of OmniAb is the ability to engineer animals to generate affinity matured human sequence antibodies for use in conventional and novel formats.  We leverage our proprietary animals with state-of-the-art technology in antigen design, immunization methods and high-throughput single B cell screening to facilitate discovery of best-in-class antibodies.   We are looking for accomplished team players who are enthusiastic to contribute to the technological frontier of antibody discovery, and passionate in their desire to collaborate with partners to develop next generation therapeutics.  See for more details about the exciting science being performed at Ligand

About Ligand    •    Ligand is a biopharmaceutical company focused on developing or acquiring technologies that help pharmaceutical companies discover and develop medicines. Ligand employs research technologies such as antibody discovery technologies, ion channel discovery technology, Pseudomonas fluorescens protein expression technology, formulation science and liver targeted pro-drug technologies to assist companies in their work toward securing prescription drug and biologic approvals. We have contributed novel research and technologies for approved medicines that treat cancer, osteoporosis, fungal infections and postpartum depression, among others. 

Essential Role Responsibilities

  • Independently plan and carry out antibody expression, purification and analysis
  • Conduct PCR, molecular cloning and site-directed mutagenesis
  • Design and execute analytical assays of antibody properties
  • Perform transfections and propagate mammalian tissue culture cell lines
  • Maintain an accurate electronic lab notebook and present data at group meetings
  • Prepare experimental data reports for partner and internal antibody discovery programs

Non-essential Role Responsibilities Include

  • Deliver presentations at major antibody conferences
  • Other duties as required

Minimum Requirements

  • PhD with 2+ years relevant experience
  • BS or MS in Biology or equivalent, with extensive industry experience (7-12 years) including antibody discovery
  • Experience in antibody cloning, expression and/or purification
  • Experience in antibody engineering
  • Experience with techniques for antibody characterization such as BLI/SPR, ELISA, FACS and cellular assays
  • Experience in mammalian cell culture
  • Experience in yeast or phage display is preferred
  • Experience in project management is preferred
  • Eagerness to learn new methods and apply knowledge to a steady stream of new projects with distinct goals
  • Must demonstrate well-developed communication, record keeping, organizational skills, and the ability to work in a team environment

Ligand is an EEO/AA/Disability/Vets employer.

Apply Here

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