Research Scientist, Cell & Molecular Biology

The Research Scientist position reports to the Director, Molecular Biology supporting Ligand’s OmniAb Technology platform and will work on a team that generates and characterizes new strains of OmniChickens.  Duties include responsibility for Ligand’s cell bank of primordial germ cells (PGCs) and, propagate and genetically modify the cells to incorporate novel transgenes with enhanced capabilities.  Plan and coordinate the production of germline chimeras by reintroduction of the PGCs back into embryos.  Participate in construct building and molecular characterization of genetically modified PGCs and the characterization and evaluation of new OmniAb chickens once they have been established.  Characterization of new chickens includes studying B cell development, antibody repertoires, immune responses and/ or antibody discovery.  

The OmniAb group at Ligand consists of dynamic and innovative scientists that employ a variety of novel platforms to support our partners in discovering the best antibodies possible for their therapeutic applications.  At the core of OmniAb is the ability to engineer animals to generate affinity matured human sequence antibodies for use in conventional and novel formats.  We leverage our proprietary animals with state-of-the-art technology in antigen design, immunization methods and high-throughput single B cell screening to facilitate discovery of best-in-class antibodies.   We are looking for accomplished team players who are enthusiastic to contribute to the technological frontier of antibody discovery, and passionate in their desire to collaborate with partners to develop next generation therapeutics.  See OmniAb.com for more details about the exciting science being performed at Ligand.

About Ligand    •    Ligand is a biopharmaceutical company focused on developing or acquiring technologies that help pharmaceutical companies discover and develop medicines. Ligand employs research technologies such as antibody discovery technologies, ion channel discovery technology, Pseudomonas fluorescens protein expression technology, formulation science and liver targeted pro-drug technologies to assist companies in their work toward securing prescription drug and biologic approvals. We have contributed novel research and technologies for approved medicines that treat cancer, osteoporosis, fungal infections and postpartum depression, among others. 

Essential Role Responsibilities

  • PGC culture, transfection and chimera production
  • Molecular characterization of PGC lines and transgenes

Additional Responsibilities Include

  • Immunophenotyping of OmniAb birds
  • Presentations at major antibody conferences
  • Other duties as required

Experience and skills

  • PhD with 2+ yrs relevant experience
  • Demonstrated aptitude with embryo culture or primary cell culture, such as pluripotent stem cells or equivalent challenging primary cell culture
  • Experience in transgenic animals preferred
  • A strong molecular biology background
  • Experience in immunology and immunological techniques preferred
  • Must demonstrate well-developed communication, record keeping, organizational skills, and the ability to work in a team environment

Benefits

The company offers competitive benefits including medical, dental, vision, Short/Long term disability and life insurance, as well as 401(k) match, Stock Options, Bonus, and paid time leave

Additional Information

All new hires are required to go through a background and reference check
Ligand is an EEO/AA/Disability/Vets employer
Must be legally authorized to work in the US without sponsorship
Ligand celebrates the diversity of life and welcomes all individuals to apply No agencies or phone calls please

Apply Here

« Back to Careers